منابع مشابه
Lipotoxicity in the heart.
Cardiomyopathy is associated with both rare genetic metabolic abnormalities and highly prevalent diseases characterized by elevated serum triglycerides and nonesterified fatty acids, such as obesity and type 2 diabetes. In these disorders, an imbalance between fatty acid uptake and utilization leads to the inappropriate accumulation of free fatty acids and neutral lipids within cardiomyocytes. ...
متن کاملGlutamine Modulates Macrophage Lipotoxicity
Obesity and diabetes are associated with excessive inflammation and impaired wound healing. Increasing evidence suggests that macrophage dysfunction is responsible for these inflammatory defects. In the setting of excess nutrients, particularly dietary saturated fatty acids (SFAs), activated macrophages develop lysosome dysfunction, which triggers activation of the NLRP3 inflammasome and cell d...
متن کاملUpdate in podocyte biology.
Knowledge of podocyte biology is growing rapidly. Podocytes are crucially involved in most hereditary diseases affecting the glomerulus, which all exhibit podocyte-specific defects, that is, foot process effacement and protein leakage. Efforts to understand molecular mechanisms causing these derangements are increasingly successful and will allow a better targeting of interventions to halt the ...
متن کاملInsulin in podocyte podiatry
Diabetic nephropathy, a major complication of diabetes mellitus, is the leading cause of end-stage renal disease worldwide and recently it has been recognized as a high risk for the development of cardiovascular disease. Clinical features of diabetic nephropathy are development of albuminuria followed by persistent proteinuria and, later, reduction of glomerular filtration rate. Chronic hypergl...
متن کاملThe Role of Lipotoxicity in Smoke Cardiomyopathy
BACKGROUND/AIMS Experimental and clinical studies have shown the direct toxic effects of cigarette smoke (CS) on the myocardium, independent of vascular effects. However, the underlying mechanisms are not well known. METHODS Wistar rats were allocated to control (C) and cigarette smoke (CS) groups. CS rats were exposed to cigarette smoke for 2 months. RESULTS After that morphometric, functi...
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ژورنال
عنوان ژورنال: Kidney360
سال: 2021
ISSN: 2641-7650
DOI: 10.34067/kid.0006152020